diff --git a/gcc/lower-subreg.cc b/gcc/lower-subreg.cc
index 81fc5380..7c9cc3c 100644
--- a/gcc/lower-subreg.cc
+++ b/gcc/lower-subreg.cc
@@ -1086,9 +1086,6 @@ resolve_simple_move (rtx set, rtx_insn *insn)
     {
       unsigned int i;
 
-      if (REG_P (dest) && !HARD_REGISTER_NUM_P (REGNO (dest)))
-	emit_clobber (dest);
-
       for (i = 0; i < words; ++i)
 	{
 	  rtx t = simplify_gen_subreg_concatn (word_mode, dest,
diff --git a/gcc/testsuite/gcc.target/i386/pr43644.c b/gcc/testsuite/gcc.target/i386/pr43644.c
new file mode 100644
index 0000000..ffdf31c
--- /dev/null
+++ b/gcc/testsuite/gcc.target/i386/pr43644.c
@@ -0,0 +1,11 @@
+/* { dg-do compile { target int128 } } */
+/* { dg-options "-O2" } */
+
+__int128 foo(__int128 x, __int128 y)
+{
+  return x+y;
+}
+
+/* { dg-final { scan-assembler-times "movq" 2 } } */
+/* { dg-final { scan-assembler-not "push" } } */
+/* { dg-final { scan-assembler-not "pop" } } */