--- a/gdb/remote.c
+++ b/gdb/remote.c
@@ -8244,6 +8244,12 @@ remote_insert_breakpoint (struct gdbarch
 	}
     }
 
+  /* If this breakpoint has target-side commands but this stub doesn't
+     support Z0 packets, throw error.  */
+  if (!VEC_empty (agent_expr_p, bp_tgt->tcommands))
+    error (_("\
+Target doesn't support breakpoints that have target side commands."));
+
   return memory_insert_breakpoint (gdbarch, bp_tgt);
 }